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That creates uncertainty in areas such as: long-term use beyond typical protocol durations rare side effects that require large sample sizes to detect interactions with complex medication regimens outcomes in special populations such as pregnancy, cancer history, or severe autoimmune disease The right response to uncertainty is not fear, and it is not blind confidence

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Acknowledgments The authors would like to thank Cagla Ayhan, MD from KAPPA Training Consultancy Research LLC, Izmir, Turkey who provided editorial support funded by Abdi Ibrahim Pharmaceuticals Turkey